The platform has established various animal models and can provide multiple in vivo pharmacological testing research services. We simulate and establish animal models of different pathogenic pathways based on different pathogenic mechanisms, making the animal models more closely resemble the human disease state. The technical team has completed a number of animal tests and accumulated a large number of preclinical efficacy evaluation data, especially in the research fields of fibrosis, obesity, diabetes and osteoporosis.
| Disease type | Inducing method/model |
| Liver injury/fibrosis/cirrhosis | Acute liver injury, mouse model/CCl4 induced liver injury, liver fibrosis, mouse model/bile duct ligation (BDL) induced liver fibrosis, mouse model/thioacetamide (TAA) induced liver fibrosis, mouse model |
| NAFLD/NASH | MCD and CDAA feed induced rat and mouse models/high-fat and high cholesterol feed induced rat and mouse models |
| renal fibrosis | Acute renal fibrosis rat and mouse models |
Lung injury/pulmonary fibrosis | Silicon dioxide, BLM, LPS induced acute lung injury/pulmonary fibrosis models in mice and rats |
| osteoporosis | Ovariectomy (OVX), retinoic acid induced rat and mouse models |
| obesity | DIO high-fat diet induces rat and mouse models |
| Diabetes/diabetes nephropathy | Db/db mouse model/ob mouse/ZDF rat model/STZ induced type I diabetes rat model |
| Natural aging diseases | Elderly mice |
| Animal experimental testing for other diseases | OGTT, ITT, etc |
The company currently has a series of cell-based drug in vitro activity evaluation platforms, focusing on drug molecule in vitro activity detection, drug screening, molecular biology research, and cell model construction. They can scientifically evaluate the drug properties of drug molecules and assist customers in obtaining molecules with excellent pharmacological activity. Screening and functional testing of drugs in vitro are key aspects of early detection and drug efficacy evaluation of candidate drug molecules.
| Service Name | Content |
| Cellular Functionalism and Drug Screening | Construction of working cell lines: Establishment of corresponding cell models for in vitro activity evaluation of different types of drugs (small molecules, peptides, etc.) |
| Drug screening and functional activity research: cell proliferation detection, cell movement, and cell apoptosis, etc | |
| Molecular Biology Platform | Research on Drug Mechanisms of Action: Signal Pathway Studies, Bioinformatics Analysis, etc |
| Development of drug in vitro evaluation methods: cell+drug treatment+functional testing/mechanism validation | |
| Receptor agonist activity assay | GLP-1R,、GCGR、GIPR等受体激动活性测定 |
| cell proliferation | cell counting |
| Growth curve determination | |
| Survival curve determination | |
| Proliferation detection (CTG, CCK8, MTT) | |
| BrDU detection immunofluorescence method | |
| Cell Movement | Transwell detects cell migration |
| Transwell detects cell invasion | |
| apoptosis | WB detection of apoptosis related proteins |
| Tunel staining (DAB staining) |
Provide comprehensive preclinical pharmacokinetic (PK) research services, mainly providing in vivo pharmacokinetic services.
In vivo pharmacokinetic evaluation
| Genus | Route of administration | Biological matrix |
| Mice, rats, guinea pigs. | Oral, intravenous or drip administration, subcutaneous injection, intraperitoneal injection, intramuscular injection or local administration, etc. | Whole blood and plasma. |
Case Showcase
Blood drug concentration time curve
Phone：
0755-89999890
Email：
sztwac@turierbio.com
Address：
901, Building B, Baitai Gold Jewelry Building, Laokeng Community, Longtian Street, Pingshan, Shenzhen
